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DNA-damage-responsive acetylation of pRb regulates binding to E2F-1

The pRb (retinoblastoma protein) tumour suppressor protein has a crucial role in regulating the G1- to S-phase transition, and its phosphorylation by cyclin-dependent kinases is an established and important mechanism in controlling pRb activity. In addition, the targeted acetylation of lysine (K) re...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Markham, Douglas, Munro, Shonagh, Soloway, Judith, O'Connor, Darran P, La Thangue, Nicholas B
פורמט: Artigo
שפה:Inglês
יצא לאור: 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369245/
https://ncbi.nlm.nih.gov/pubmed/16374512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400591
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