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Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

As a critical target for cyclin-dependent kinases (Cdks), the retinoblastoma tumour suppressor protein (pRb) controls early cell cycle progression. We report here a new type of regulation that influences Cdk recognition and phosphorylation of substrate proteins, mediated through the targeted methyla...

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Main Authors: Carr, Simon M, Munro, Shonagh, Kessler, Benedikt, Oppermann, Udo, La Thangue, Nicholas B
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025457/
https://ncbi.nlm.nih.gov/pubmed/21119616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.311
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