Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that...

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Detalles Bibliográficos
Main Authors: Carr, Simon M., Munro, Shonagh, Zalmas, Lykourgos-Panagiotis, Fedorov, Oleg, Johansson, Catrine, Krojer, Tobias, Sagum, Cari A., Bedford, Mark T., Oppermann, Udo, La Thangue, Nicholas B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128150/
https://ncbi.nlm.nih.gov/pubmed/25049398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403737111
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