Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Rheumatoid arthritis (RA) is a chronic autoinflammatory disease that affects 1-2% of the world population and is characterized by widespread joint inflammation. IL-1 is an important mediator of cartilage destruction in rheumatic diseases(1), but our understanding of the upstream mechanisms leading t...

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Autors principals: Walle, Lieselotte Vande, Van Opdenbosch, Nina, Jacques, Peggy, Fossoul, Amelie, Verheugen, Eveline, Vogel, Peter, Beyaert, Rudi, Elewaut, Dirk, Kanneganti, Thirumala-Devi, van Loo, Geert, Lamkanfi, Mohamed
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126806/
https://ncbi.nlm.nih.gov/pubmed/25043000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13322
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