Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

The Nlrc4 inflammasome contributes to immunity against intracellular pathogens that express flagellin and type III secretion systems, and activating mutations in NLRC4 cause autoinflammation in patients. Both Naip5 and phosphorylation of Nlrc4 at Ser533 are required for flagellin-induced inflammasom...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Matusiak, Magdalena, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Sirard, Jean-Claude, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321312/
https://ncbi.nlm.nih.gov/pubmed/25605939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417945112
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