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Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
The Nlrc4 inflammasome contributes to immunity against intracellular pathogens that express flagellin and type III secretion systems, and activating mutations in NLRC4 cause autoinflammation in patients. Both Naip5 and phosphorylation of Nlrc4 at Ser533 are required for flagellin-induced inflammasom...
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| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4321312/ https://ncbi.nlm.nih.gov/pubmed/25605939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417945112 |
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