Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

The Nlrc4 inflammasome contributes to immunity against intracellular pathogens that express flagellin and type III secretion systems, and activating mutations in NLRC4 cause autoinflammation in patients. Both Naip5 and phosphorylation of Nlrc4 at Ser533 are required for flagellin-induced inflammasom...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Matusiak, Magdalena, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Sirard, Jean-Claude, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321312/
https://ncbi.nlm.nih.gov/pubmed/25605939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417945112
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