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Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

Coronaviruses and arteriviruses, members of the order Nidovirales, are positive strand RNA viruses that encode large replicase polyproteins that are processed by viral proteases to generate the nonstructural proteins which mediate viral RNA synthesis. The viral papain-like proteases (PLPs) are criti...

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Bibliographic Details
Main Authors: Mielech, Anna M., Chen, Yafang, Mesecar, Andrew D., Baker, Susan C.
Format: Artigo
Language:Inglês
Published: Elsevier B.V. 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125544/
https://ncbi.nlm.nih.gov/pubmed/24512893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2014.01.025
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