Imatinib Analogs as Potential Agents for PET Imaging of Bcr-Abl/c-KIT Expression at a Kinase Level

We synthesized two series of imatinib mesylate (STI-571) analogs to develop a Bcr-Abl and c-KIT receptor-specific labeling agent for positron emission tomography (PET) imaging to measure Bcr-Abl and c-KIT expression levels in a mouse model. The methods of molecular modeling, synthesis of STI-571 and...

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Detalhes bibliográficos
Main Authors: Peng, Zhenghong, Maxwell, David S., Sun, Duoli, Bhanu Prasad, Basvoju A., Pal, Ashutosh, Wang, Shimei, Balatoni, Julius, Ghosh, Pradip, Lim, Seok T., Volgin, Andrei, Shavrin, Aleksander, Alauddin, Mian M., Gelovani, Juri G., Bornmann, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124913/
https://ncbi.nlm.nih.gov/pubmed/24280068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.10.040
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