Imatinib Analogs as Potential Agents for PET Imaging of Bcr-Abl/c-KIT Expression at a Kinase Level

We synthesized two series of imatinib mesylate (STI-571) analogs to develop a Bcr-Abl and c-KIT receptor-specific labeling agent for positron emission tomography (PET) imaging to measure Bcr-Abl and c-KIT expression levels in a mouse model. The methods of molecular modeling, synthesis of STI-571 and...

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Main Authors: Peng, Zhenghong, Maxwell, David S., Sun, Duoli, Bhanu Prasad, Basvoju A., Pal, Ashutosh, Wang, Shimei, Balatoni, Julius, Ghosh, Pradip, Lim, Seok T., Volgin, Andrei, Shavrin, Aleksander, Alauddin, Mian M., Gelovani, Juri G., Bornmann, William G.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124913/
https://ncbi.nlm.nih.gov/pubmed/24280068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.10.040
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