Imatinib Analogs as Potential Agents for PET Imaging of Bcr-Abl/c-KIT Expression at a Kinase Level

We synthesized two series of imatinib mesylate (STI-571) analogs to develop a Bcr-Abl and c-KIT receptor-specific labeling agent for positron emission tomography (PET) imaging to measure Bcr-Abl and c-KIT expression levels in a mouse model. The methods of molecular modeling, synthesis of STI-571 and...

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Bibliografski detalji
Glavni autori: Peng, Zhenghong, Maxwell, David S., Sun, Duoli, Bhanu Prasad, Basvoju A., Pal, Ashutosh, Wang, Shimei, Balatoni, Julius, Ghosh, Pradip, Lim, Seok T., Volgin, Andrei, Shavrin, Aleksander, Alauddin, Mian M., Gelovani, Juri G., Bornmann, William G.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124913/
https://ncbi.nlm.nih.gov/pubmed/24280068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.10.040
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