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MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells
Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here we provide evidence that MLL-ENL also inhibits polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies identified ENL as scaffold that contacted the elongatio...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4124133/ https://ncbi.nlm.nih.gov/pubmed/23623499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.038 |
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