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MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells

Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here we provide evidence that MLL-ENL also inhibits polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies identified ENL as scaffold that contacted the elongatio...

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Main Authors: Maethner, Emanuel, Garcia-Cuellar, Maria-Paz, Breitinger, Constanze, Takacova, Sylvia, Divoky, Vladimir, Hess, Jay L., Slany, Robert K.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124133/
https://ncbi.nlm.nih.gov/pubmed/23623499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.038
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