A carregar...
MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells
Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here we provide evidence that MLL-ENL also inhibits polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies identified ENL as scaffold that contacted the elongatio...
Na minha lista:
| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4124133/ https://ncbi.nlm.nih.gov/pubmed/23623499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.038 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|