ロード中...
MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells
Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here we provide evidence that MLL-ENL also inhibits polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies identified ENL as scaffold that contacted the elongatio...
保存先:
| 主要な著者: | , , , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4124133/ https://ncbi.nlm.nih.gov/pubmed/23623499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.038 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|