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β(2)-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH

Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β(2)-microglobulin (β(2)m), associated with dialysis-related amyloi...

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Main Authors: Goodchild, Sophia C., Sheynis, Tania, Thompson, Rebecca, Tipping, Kevin W., Xue, Wei-Feng, Ranson, Neil A., Beales, Paul A., Hewitt, Eric W., Radford, Sheena E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123989/
https://ncbi.nlm.nih.gov/pubmed/25100247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104492
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