β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), a su...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Jakhria, Toral, Hellewell, Andrew L., Porter, Morwenna Y., Jackson, Matthew P., Tipping, Kevin W., Xue, Wei-Feng, Radford, Sheena E., Hewitt, Eric W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2014
विषय:
Molecular Bases of Disease
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276847/
https://ncbi.nlm.nih.gov/pubmed/25378395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586222
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