β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), a su...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Jakhria, Toral, Hellewell, Andrew L., Porter, Morwenna Y., Jackson, Matthew P., Tipping, Kevin W., Xue, Wei-Feng, Radford, Sheena E., Hewitt, Eric W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276847/
https://ncbi.nlm.nih.gov/pubmed/25378395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586222
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