β(2)-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), a su...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jakhria, Toral, Hellewell, Andrew L., Porter, Morwenna Y., Jackson, Matthew P., Tipping, Kevin W., Xue, Wei-Feng, Radford, Sheena E., Hewitt, Eric W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276847/
https://ncbi.nlm.nih.gov/pubmed/25378395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586222
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