Direct three-dimensional visualization of membrane disruption by amyloid fibrils

Protein misfolding and aggregation cause serious degenerative conditions such as Alzheimer’s, Parkinson, and prion diseases. Damage to membranes is thought to be one of the mechanisms underlying cellular toxicity of a range of amyloid assemblies. Previous studies have indicated that amyloid fibrils...

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Detalhes bibliográficos
Main Authors: Milanesi, Lilia, Sheynis, Tania, Xue, Wei-Feng, Orlova, Elena V., Hellewell, Andrew L., Jelinek, Raz, Hewitt, Eric W., Radford, Sheena E., Saibil, Helen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528594/
https://ncbi.nlm.nih.gov/pubmed/23184970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206325109
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