β(2)-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH

Although the molecular mechanisms underlying the pathology of amyloidoses are not well understood, the interaction between amyloid proteins and cell membranes is thought to play a role in several amyloid diseases. Amyloid fibrils of β(2)-microglobulin (β(2)m), associated with dialysis-related amyloi...

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Main Authors: Goodchild, Sophia C., Sheynis, Tania, Thompson, Rebecca, Tipping, Kevin W., Xue, Wei-Feng, Ranson, Neil A., Beales, Paul A., Hewitt, Eric W., Radford, Sheena E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123989/
https://ncbi.nlm.nih.gov/pubmed/25100247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104492
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