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pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers
Amyloid disorders cause debilitating illnesses through the formation of toxic protein aggregates. The mechanisms of amyloid toxicity and the nature of species responsible for mediating cellular dysfunction remain unclear. Here, using β(2)-microglobulin (β(2)m) as a model system, we show that the dis...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4426459/ https://ncbi.nlm.nih.gov/pubmed/25902516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423174112 |
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