pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

Amyloid disorders cause debilitating illnesses through the formation of toxic protein aggregates. The mechanisms of amyloid toxicity and the nature of species responsible for mediating cellular dysfunction remain unclear. Here, using β(2)-microglobulin (β(2)m) as a model system, we show that the dis...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Tipping, Kevin W., Karamanos, Theodoros K., Jakhria, Toral, Iadanza, Matthew G., Goodchild, Sophia C., Tuma, Roman, Ranson, Neil A., Hewitt, Eric W., Radford, Sheena E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426459/
https://ncbi.nlm.nih.gov/pubmed/25902516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423174112
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