लोड हो रहा है...
pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers
Amyloid disorders cause debilitating illnesses through the formation of toxic protein aggregates. The mechanisms of amyloid toxicity and the nature of species responsible for mediating cellular dysfunction remain unclear. Here, using β(2)-microglobulin (β(2)m) as a model system, we show that the dis...
में बचाया:
| में प्रकाशित: | Proc Natl Acad Sci U S A |
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| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4426459/ https://ncbi.nlm.nih.gov/pubmed/25902516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423174112 |
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