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SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

Genetic studies revealed that SHIP1 limits blood cell production and immune regulatory cell numbers in vivo. We postulated that molecular targeting of SHIP1 might enhance blood cell production and increase immunoregulatory capacity. In this study, we report the identification of a chemical inhibitor...

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Hlavní autoři: Brooks, Robert, Fuhler, Gwenny M., Iyer, Sonia, Smith, Michelle J., Park, Mi-Young, Paraiso, Kim H. T., Engelman, Robert W., Kerr, William G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123216/
https://ncbi.nlm.nih.gov/pubmed/20200281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902844
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