SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

Genetic studies revealed that SHIP1 limits blood cell production and immune regulatory cell numbers in vivo. We postulated that molecular targeting of SHIP1 might enhance blood cell production and increase immunoregulatory capacity. In this study, we report the identification of a chemical inhibitor...

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Main Authors: Brooks, Robert, Fuhler, Gwenny M., Iyer, Sonia, Smith, Michelle J., Park, Mi-Young, Paraiso, Kim H. T., Engelman, Robert W., Kerr, William G.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123216/
https://ncbi.nlm.nih.gov/pubmed/20200281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902844
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