SHIP limits immunoregulatory capacity in the T-cell compartment

Regulatory T cells (T(regs)) play a pivotal role in preventing autoimmunity, graft-versus-host disease (GVHD), and organ graft rejection. We previously showed that either germline or induced SH2 domain–containing inositol 5-phosphatase (SHIP) deficiency in the host abrogates GVHD. Here we show that...

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Autori principali: Collazo, Michelle M., Wood, Daniela, Paraiso, Kim H. T., Lund, Erin, Engelman, Robert W., Le, Cam-Tien, Stauch, Diana, Kotsch, Katja, Kerr, William G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662640/
https://ncbi.nlm.nih.gov/pubmed/19136659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-181164
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