Polymorphisms at Amino Acid Residues 141 and 154 Influence Conformational Variation in Ovine PrP

Polymorphisms in ovine PrP at amino acid residues 141 and 154 are associated with susceptibility to ovine prion disease: Leu141Arg154 with classical scrapie and Phe141Arg154 and Leu141His154 with atypical scrapie. Classical scrapie is naturally transmissible between sheep, whereas this may not be th...

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Autores principales: Yang, Sujeong, Thackray, Alana M., Hopkins, Lee, Monie, Tom P., Burke, David F., Bujdoso, Raymond
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122135/
https://ncbi.nlm.nih.gov/pubmed/25126555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/372491
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