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p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization
Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we demo...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4121573/ https://ncbi.nlm.nih.gov/pubmed/24895282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00010.2014 |
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