Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. To address this problem, we used a systems-based discovery strategy to search for a small molecule whose mRNA expression signature negatively correlates to mRNA expression signatures of human skeletal mus...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dyle, Michael C., Ebert, Scott M., Cook, Daniel P., Kunkel, Steven D., Fox, Daniel K., Bongers, Kale S., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Metabolism
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031541/
https://ncbi.nlm.nih.gov/pubmed/24719321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.556241
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