Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

Diverse stresses including starvation and muscle disuse cause skeletal muscle atrophy. However, the molecular mechanisms of muscle atrophy are complex and not well understood. Here, we demonstrate that growth arrest and DNA damage-inducible 45a protein (Gadd45a) is a critical mediator of muscle atro...

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Main Authors: Ebert, Scott M., Dyle, Michael C., Kunkel, Steven D., Bullard, Steven A., Bongers, Kale S., Fox, Daniel K., Dierdorff, Jason M., Foster, Eric D., Adams, Christopher M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431665/
https://ncbi.nlm.nih.gov/pubmed/22692209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374777
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