Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular mechanisms of age-related skeletal muscle weakness and atrophy as well as new potential interventions for these conditions. We identified two s...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Ebert, Scott M., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Murry, Daryl J., Fox, Daniel K., Bongers, Kale S., Lira, Vitor A., Meyerholz, David K., Talley, John J., Adams, Christopher M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646196/
https://ncbi.nlm.nih.gov/pubmed/26338703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.681445
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars