p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we demo...

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Main Authors: Fox, Daniel K., Ebert, Scott M., Bongers, Kale S., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Kunkel, Steven D., Adams, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121573/
https://ncbi.nlm.nih.gov/pubmed/24895282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00010.2014
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