p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Immobilization causes skeletal muscle atrophy via complex signaling pathways that are not well understood. To better understand these pathways, we investigated the roles of p53 and ATF4, two transcription factors that mediate adaptations to a variety of cellular stresses. Using mouse models, we demo...

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Bibliographic Details
Main Authors: Fox, Daniel K., Ebert, Scott M., Bongers, Kale S., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Kunkel, Steven D., Adams, Christopher M.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121573/
https://ncbi.nlm.nih.gov/pubmed/24895282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00010.2014
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