BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Anti-tumor Activity of Adoptive Immunotherapy in Mice

PURPOSE: Treatment of melanoma patients with selective BRAF inhibitors results in objective clinical responses in the majority of patients with BRAF mutant tumors. However, resistance to these inhibitors develops within a few months. In this study, we test the hypothesis that BRAF inhibition in comb...

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Detalhes bibliográficos
Main Authors: Liu, Chengwen, Peng, Weiyi, Xu, Chunyu, Lou, Yanyan, Zhang, Minying, Wargo, Jennifer A., Chen, Jie Qing, Li, Haiyan S., Watowich, Stephanie S., Yang, Yan, Frederick, Dennie Tompers, Cooper, Zachary A., Mbofung, Rina M, Whittington, Mayra, Flaherty, Keith T., Woodman, Scott E., Davies, Michael A., Radvanyi, Laszlo G., Overwijk, Willem W., Lizée, Gregory, Hwu, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120472/
https://ncbi.nlm.nih.gov/pubmed/23204132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1626
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