Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails to Protect Against High-Dose Mycobacterium tuberculosis Challenge

Development of a vaccine against pulmonary tuberculosis (TB) may require immunization strategies that induce a high frequency of antigen-specific CD4 and CD8 T cells in the lung. The nonhuman primate (NHP) model is essential for testing such approaches because it has predictive value for how vaccine...

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Main Authors: Darrah, Patricia A., Bolton, Diane L., Lackner, Andrew A., Kaushal, Deepak, Aye, Pyone Pyone, Mehra, Smriti, Blanchard, James L., Didier, Peter J., Roy, Chad J., Rao, Srinivas S., Hokey, David A., Scanga, Charles A., Sizemore, Donata R., Sadoff, Jerald C., Roederer, Mario, Seder, Robert A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119487/
https://ncbi.nlm.nih.gov/pubmed/25024382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400676
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