A Phase I, Open-Label Trial, Evaluating the Safety and Immunogenicity of Candidate Tuberculosis Vaccines AERAS-402 and MVA85A, Administered by Prime-Boost Regime in BCG-Vaccinated Healthy Adults

BACKGROUND: MVA85A and AERAS-402 are two clinically advanced viral vectored TB vaccine candidates expressing Mycobacterium tuberculosis antigens designed to boost BCG-induced immunity. Clinical trials with candidate malaria vaccines have demonstrated that adenoviral vector based priming immunisation...

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Pubblicato in:PLoS One
Autori principali: Sheehan, Sharon, Harris, Stephanie A., Satti, Iman, Hokey, David A., Dheenadhayalan, Veerabadran, Stockdale, Lisa, Manjaly Thomas, Zita-Rose, Minhinnick, Alice, Wilkie, Morven, Vermaak, Samantha, Meyer, Joel, O’Shea, Matthew K., Pau, Maria Grazia, Versteege, Isabella, Douoguih, Macaya, Hendriks, Jenny, Sadoff, Jerald, Landry, Bernard, Moss, Paul, McShane, Helen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631471/
https://ncbi.nlm.nih.gov/pubmed/26529238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141687
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