Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial

BACKGROUND: There is an urgent need for an effective tuberculosis (TB) vaccine. Heterologous prime–boost regimens induce potent cellular immunity. MVA85A is a candidate TB vaccine. This phase I clinical trial was designed to evaluate whether alternating aerosol and intradermal vaccination routes wou...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Manjaly Thomas, Zita-Rose, Satti, Iman, Marshall, Julia L., Harris, Stephanie A., Lopez Ramon, Raquel, Hamidi, Ali, Minhinnick, Alice, Riste, Michael, Stockdale, Lisa, Lawrie, Alison M., Vermaak, Samantha, Wilkie, Morven, Bettinson, Henry, McShane, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6490884/
https://ncbi.nlm.nih.gov/pubmed/31039172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002790
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