A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs

Bacille Calmette-Guérin (BCG), the only licensed vaccine for the prevention of tuberculosis (TB), provides only limited protection against certain forms of Mycobacterium tuberculosis (Mtb) infection. While infection with Mtb can be treated with antibiotics, the therapy is expensive, toxic, and requi...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Hokey, David A, Wachholder, Robert, Darrah, Patricia A, Bolton, Diane L, Barouch, Dan H, Hill, Krystal, Dheenadhayalan, Veerabadran, Schwander, Stephan, Godin, C Steven, Douoguih, Macaya, Pau, Maria Grazia, Seder, Robert A, Roederer, Mario, Sadoff, Jerald C, Sizemore, Donata
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896762/
https://ncbi.nlm.nih.gov/pubmed/25424923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.29108
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