The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4(+) and CD8(+) T Cells in Adults

Rationale: AERAS-402 is a novel tuberculosis vaccine designed to boost immunity primed by bacillus Calmette-Guérin (BCG), the only licensed vaccine. Objectives: We investigated the safety and immunogenicity of AERAS-402 in healthy Mycobacterium tuberculosis–uninfected BCG-vaccinated adults from a tu...

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Main Authors: Abel, Brian, Tameris, Michele, Mansoor, Nazma, Gelderbloem, Sebastian, Hughes, Jane, Abrahams, Deborah, Makhethe, Lebohang, Erasmus, Mzwandile, Kock, Marwou de, van der Merwe, Linda, Hawkridge, Anthony, Veldsman, Ashley, Hatherill, Mark, Schirru, Giulia, Pau, Maria Grazia, Hendriks, Jenny, Weverling, Gerrit Jan, Goudsmit, Jaap, Sizemore, Donata, McClain, J. Bruce, Goetz, Margaret, Gearhart, Jacqueline, Mahomed, Hassan, Hussey, Gregory D., Sadoff, Jerald C., Hanekom, Willem A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2010
Assuntos:
H. Tuberculosis and Mycobacterial Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894413/
https://ncbi.nlm.nih.gov/pubmed/20167847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200910-1484OC
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