Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails to Protect Against High-Dose Mycobacterium tuberculosis Challenge

Eitemau Tebyg

• A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs
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  Cyhoeddwyd: (2014)
• The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4(+) and CD8(+) T Cells in Adults
  gan: Abel, Brian, et al.
  Cyhoeddwyd: (2010)
• Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine
  gan: Nyendak, Melissa, et al.
  Cyhoeddwyd: (2016)
• A 2-Dose AERAS-402 Regimen Boosts CD8(+) Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients
  gan: Sivakumaran, Dhanasekaran, et al.
  Cyhoeddwyd: (2021)
• A Phase I, Open-Label Trial, Evaluating the Safety and Immunogenicity of Candidate Tuberculosis Vaccines AERAS-402 and MVA85A, Administered by Prime-Boost Regime in BCG-Vaccinated Healthy Adults
  gan: Sheehan, Sharon, et al.
  Cyhoeddwyd: (2015)