Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis

Sequence variation in tRNA genes influences the structure, modification, and stability of tRNA; affects translation fidelity; impacts the activity of numerous isodecoders in metazoans; and leads to human diseases. To comprehensively define the effects of sequence variation on tRNA function, we devel...

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Hlavní autoři: Guy, Michael P., Young, David L., Payea, Matthew J., Zhang, Xiaoju, Kon, Yoshiko, Dean, Kimberly M., Grayhack, Elizabeth J., Mathews, David H., Fields, Stanley, Phizicky, Eric M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
Témata:
Resource/Methodology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117946/
https://ncbi.nlm.nih.gov/pubmed/25085423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.245936.114
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