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Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast
During tRNA maturation in yeast, aberrant pre-tRNAs are targeted for 3′–5′ degradation by the nuclear surveillance pathway, and aberrant mature tRNAs are targeted for 5′–3′ degradation by the rapid tRNA decay (RTD) pathway. RTD is catalyzed by the 5′–3′ exonucleases Xrn1 and Rat1, which act on tRNAs...
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| Publicado no: | RNA |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6913130/ https://ncbi.nlm.nih.gov/pubmed/31619505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073155.119 |
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