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Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway

Modification defects in the tRNA anticodon loop often impair yeast growth and cause human disease. In the budding yeast Saccharomyces cerevisiae and the phylogenetically distant fission yeast Schizosaccharomyces pombe, trm7Δ mutants grow poorly due to lack of 2'-O-methylation of C(32) and G(34)...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Han, Lu, Guy, Michael P., Kon, Yoshiko, Phizicky, Eric M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892943/
https://ncbi.nlm.nih.gov/pubmed/29596413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007288
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