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Conservation of an intricate circuit for crucial modifications of the tRNA(Phe) anticodon loop in eukaryotes

Post-transcriptional tRNA modifications are critical for efficient and accurate translation, and have multiple different roles. Lack of modifications often leads to different biological consequences in different organisms, and in humans is frequently associated with neurological disorders. We invest...

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Bibliographic Details
Published in:RNA
Main Authors: Guy, Michael P., Phizicky, Eric M.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274638/
https://ncbi.nlm.nih.gov/pubmed/25404562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.047639.114
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