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MegaTevs: single-chain dual nucleases for efficient gene disruption
Targeting gene disruptions in complex genomes relies on imprecise repair by the non-homologous end-joining DNA pathway, creating mutagenic insertions or deletions (indels) at the break point. DNA end-processing enzymes are often co-expressed with genome-editing nucleases to enhance the frequency of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4117789/ https://ncbi.nlm.nih.gov/pubmed/25013171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku573 |
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