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megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

Rare-cleaving endonucleases have emerged as important tools for making targeted genome modifications. While multiple platforms are now available to generate reagents for research applications, each existing platform has significant limitations in one or more of three key properties necessary for the...

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Dettagli Bibliografici
Autori principali: Boissel, Sandrine, Jarjour, Jordan, Astrakhan, Alexander, Adey, Andrew, Gouble, Agnès, Duchateau, Philippe, Shendure, Jay, Stoddard, Barry L., Certo, Michael T., Baker, David, Scharenberg, Andrew M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936731/
https://ncbi.nlm.nih.gov/pubmed/24285304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1224
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