megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

Rare-cleaving endonucleases have emerged as important tools for making targeted genome modifications. While multiple platforms are now available to generate reagents for research applications, each existing platform has significant limitations in one or more of three key properties necessary for the...

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Bibliographic Details
Main Authors: Boissel, Sandrine, Jarjour, Jordan, Astrakhan, Alexander, Adey, Andrew, Gouble, Agnès, Duchateau, Philippe, Shendure, Jay, Stoddard, Barry L., Certo, Michael T., Baker, David, Scharenberg, Andrew M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936731/
https://ncbi.nlm.nih.gov/pubmed/24285304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1224
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