Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance

A naturally occurring 32-base pair deletion of the HIV-1 co-receptor CCR5 has demonstrated protection against HIV infection of human CD4(+) T cells. Recent genetic engineering approaches using engineered nucleases to disrupt the gene and mimic this mutation show promise for HIV therapy. We developed...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Romano Ibarra, Guillermo S, Paul, Biswajit, Sather, Blythe D, Younan, Patrick M, Sommer, Karen, Kowalski, John P, Hale, Malika, Stoddard, Barry, Jarjour, Jordan, Astrakhan, Alexander, Kiem, Hans-Peter, Rawlings, David J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023401/
https://ncbi.nlm.nih.gov/pubmed/27741222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.56
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