MegaTevs: single-chain dual nucleases for efficient gene disruption

Targeting gene disruptions in complex genomes relies on imprecise repair by the non-homologous end-joining DNA pathway, creating mutagenic insertions or deletions (indels) at the break point. DNA end-processing enzymes are often co-expressed with genome-editing nucleases to enhance the frequency of...

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Bibliografske podrobnosti
Main Authors: Wolfs, Jason M., DaSilva, Matthew, Meister, Sarah E., Wang, Xu, Schild-Poulter, Caroline, Edgell, David R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Synthetic Biology and Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117789/
https://ncbi.nlm.nih.gov/pubmed/25013171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku573
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