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Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease
The CRISPR/Cas9 nuclease is commonly used to make gene knockouts. The blunt DNA ends generated by cleavage can be efficiently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regenerating the target site. This repair creates a cycle of cleavage, ligation, and target site r...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206545/ https://ncbi.nlm.nih.gov/pubmed/27956611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616343114 |
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