Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons

Aging, a major risk factor in Alzheimer’s disease (AD), is associated with an oxidative redox shift, decreased redox buffer protection, and increased free radical reactive oxygen species (ROS) generation, probably linked to mitochondrial dysfunction. While NADH is the ultimate electron donor for man...

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Hlavní autoři: Ghosh, Debolina, Levault, Kelsey R, Brewer, Gregory J
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116450/
https://ncbi.nlm.nih.gov/pubmed/24655393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12216
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