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Dual energy precursor and Nrf2 activator treatment additively improve redox glutathione levels and neuron survival in aging and in Alzheimer mouse neurons upstream of ROS
To determine whether glutathione (GSH) loss or increased ROS are more important to neuron loss, aging and Alzheimer disease (AD), we stressed or boosted GSH levels in neurons isolated from aging 3xTg-AD neurons compared to age-match non-transgenic neurons (non-Tg). Here, by titrating with buthionine...
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| Veröffentlicht in: | Neurobiol Aging |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099064/ https://ncbi.nlm.nih.gov/pubmed/23954169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.06.023 |
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