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External cys/cySS redox state modification controls the intracellular redox state and neurodegeneration via Akt in aging and Alzheimer’s mouse model neurons
The extracellular redox environment of cells is mainly set by the redox couple cysteine/cystine (cys/cySS) while intracellular redox is buffered by reduced/oxidized glutathione (GSH/GSSG), but controlled by NAD(P)H/NAD(P). With aging, the extracellular redox environment shifts in the oxidized direct...
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| 出版年: | J Alzheimers Dis |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099062/ https://ncbi.nlm.nih.gov/pubmed/24844688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-132756 |
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