External cys/cySS redox state modification controls the intracellular redox state and neurodegeneration via Akt in aging and Alzheimer’s mouse model neurons

The extracellular redox environment of cells is mainly set by the redox couple cysteine/cystine (cys/cySS) while intracellular redox is buffered by reduced/oxidized glutathione (GSH/GSSG), but controlled by NAD(P)H/NAD(P). With aging, the extracellular redox environment shifts in the oxidized direct...

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Veröffentlicht in:J Alzheimers Dis
Hauptverfasser: Ghosh, Debolina, Brewer, Gregory J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099062/
https://ncbi.nlm.nih.gov/pubmed/24844688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-132756
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