The Cleaved Cytoplasmic Tail of Polycystin-1 Regulates Src-Dependent STAT3 Activation

Polycystin-1 (PC1) mutations result in proliferative renal cyst growth and progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The transcription factor STAT3 (signal transducer and activator of transcription 3) was shown to be activated in cyst-lining cells in ADPKD...

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Detalhes bibliográficos
Main Authors: Talbot, Jeffrey J., Song, Xuewen, Wang, Xiaofang, Rinschen, Markus M., Doerr, Nicholas, LaRiviere, Wells B., Schermer, Bernhard, Pei, York P., Torres, Vicente E., Weimbs, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116067/
https://ncbi.nlm.nih.gov/pubmed/24578126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013091026
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