Polycystin-1 regulates STAT activity by a dual mechanism

Mutations in polycystin-1 (PC1) lead to autosomal-dominant polycystic kidney disease (ADPKD), a leading cause of renal failure for which no treatment is available. PC1 is an integral membrane protein, which has been implicated in the regulation of multiple signaling pathways including the JAK/STAT p...

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Detalhes bibliográficos
Main Authors: Talbot, Jeffrey J., Shillingford, Jonathan M., Vasanth, Shivakumar, Doerr, Nicholas, Mukherjee, Sambuddho, Kinter, Mike T., Watnick, Terry, Weimbs, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093515/
https://ncbi.nlm.nih.gov/pubmed/21518865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103816108
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