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Regulation of STATs by polycystin-1 and their role in polycystic kidney disease

Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT transcription factors by a novel, dual mechanism. STAT3 and STAT6 are aberrantly activated in renal cysts. Genetic and pharmacological...

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Hlavní autoři: Weimbs, Thomas, Olsan, Erin E., Talbot, Jeffrey J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710321/
https://ncbi.nlm.nih.gov/pubmed/24058808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/jkst.23650
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