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Regulation of STATs by polycystin-1 and their role in polycystic kidney disease
Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT transcription factors by a novel, dual mechanism. STAT3 and STAT6 are aberrantly activated in renal cysts. Genetic and pharmacological...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710321/ https://ncbi.nlm.nih.gov/pubmed/24058808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/jkst.23650 |
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